Bifunctional Prokaryotic DNA-Methyltransferases
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On the Evolutionary Origin of Eukaryotic DNA Methyltransferases and Dnmt2
The Dnmt2 enzymes show strong amino acid sequence similarity with eukaryotic and prokaryotic DNA-(cytosine C5)-methyltransferases. Yet, Dnmt2 enzymes from several species were shown to methylate tRNA-Asp and had been proposed that eukaryotic DNA methyltransferases evolved from a Dnmt2-like tRNA methyltransferase ancestor [Goll et al., 2006, Science, 311, 395-8]. It was the aim of this study to ...
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تاریخ انتشار 2017